中国居民高血压的危险因素Meta分析
蔡婷; 黄晓玲; 曾雁冰; 方亚
目的综合评价中国居民高血压的主要危险因素,为高血压的一级预防提供循证依据。方法检索收集国内2003-2012年发表的高血压危险因素病例对照研究文献,应用lICHTEnSTEIn量表进行文献质量评估,采用META分析方法进行定量综合分析,绘制森林图,计算危险因素合并Or值及其95%置信区间,通过绘制漏斗图和计算失安全系数nfS控制偏倚。结果纳入文献37篇,各危险因素合并Or值(95%CI)由高到低依次为:糖尿病史Or=2.76(2.24,3.39);超重Or=2.61(2.19,3.11);高血压家族史Or=2.56(2.35,2.79);高盐饮食Or=1.47(1.16,1.85);饮酒Or=1.15(1.07,1.24);吸烟Or=1.14(1.05,1.23)。结论糖尿病史、超重、高血压家族史、高盐饮食、饮酒、吸烟均为中国居民高血压的危险因素。; Objective To make a comprehensive evaluation on the main risk factors of the hypertension in China, so as to provide evidences for the primary prevention of hypertension.Methods We searched and collected the literature which were case-control studies on the risk factors of the hypertension in China published from 2003 to 2012.We conducted a quality evaluation of the included literature by Lichtenstein scale.A comprehensively quantitative assessment was made by meta-analysis, including drawing forest plots, calculating the pooled odds ratio(OR) and the 95% confidence interval(95% CI).The biases were controlled according to the funnel plots and the fail-safe number(Nfs).Results A total of 37 studies are included, the pooled OR and its 95% CI of each risk factors are: diabetes 2.76(2.24, 3.39), overweight 2.61(2.19, 3.11), the family history of hypertension 2.56(2.35, 2.79),high-salt diet 1.47(1.16, 1.85), drinking 1.15(1.07, 1.24) and smoking 1.14(1.05, 1.23).Conclusions Diabetes, overweight, the family history of hypertension, high-salt diet, drinking and smoking are all risk factors of hypertension.
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