Synthesis and preliminary evaluation of novel 99mTc-labeled folate derivative via click reaction for SPECT imaging
Guo, Zhide; Zhang,; Song, Manli; Wu, Xiaowei; Liu, Chan; Zhao, Zuoqu; Lu, Jie; Zhang, Xianzhong; 张现忠
The folate receptor is over expressed in a wide variety of human tumors. In this study, a novel 99mTc-labeled folate derivative (99mTc-HYNIC-T-FA) was synthesized as a potential FR-targeting imaging probe and its efficiency was evaluated. This 99mTc-complex could be obtained through practical manner and showed improved in vivo characteristics compared with other radiofolates. Thus, this novel 99mTc-HYNIC-T-FA compound could serve as a potential imaging agent for folate receptor positive tumors. ? 2014 Elsevier Ltd.
↧